Aberrant Protein Deposition and Neurological Disease

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Aberrant protein deposition and neurological disease.

The association of protein deposits with neurodegeneration has become a consistent finding in a large group of etiologically diverse diseases (1, 2) (Table I). The protein deposits are generally dense fibrillar structures containing a high percentage of b-pleated sheet secondary structure and can be located in various cellular compartments as well as extracellularly. Moreover, the deposits are ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1999

ISSN: 0021-9258

DOI: 10.1074/jbc.274.53.37507